Atrium Therapeutics Doses First Patient in Corventis™, the First Interventional Clinical Trial for People Living with PRKAG2 Syndrome
PR Newswire•27/10/2026•06:30 ET
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Key Highlights
- ➤First patient dosed in Phase 1/2 Corventis trial evaluating ATR 1072
- ➤Corventis will enroll approximately 37 participants across two study parts
- ➤Initial proof-of-concept data expected in the second half of 2027
- ➤ATR 1072 designed to silence mutant PRKAG2 mRNA and normalize AMPK activity
- ➤PRKAG2 syndrome has no approved therapies and affects an estimated 1,000–2,000 US patients
Expert Statements
Kathleen Gallagher, President and Chief Executive Officer of Atrium Therapeutics
“Dosing the first patient in the Corventis clinical trial is a milestone for Atrium and, more importantly, for the PRKAG2 community. This is the first clinical trial for people living with PRKAG2 syndrome evaluating a potential treatment for the underlying cause of the disease. It is also an important step for the broader genetic cardiomyopathy field as it moves toward treating these diseases at their root cause”
Kathleen Gallagher, President and Chief Executive Officer of Atrium Therapeutics
“This achievement reflects the dedication of our team and was made possible by our strong partnerships with our clinical trial sites and the support of the PRKAG2 syndrome patient community.”
Michael Nassif, M.D., Heart failure cardiologist at Saint Luke's Mid America Heart Institute
“Today, the best we can offer people with PRKAG2 syndrome is a pacemaker, a defibrillator, and our best efforts to prevent life-threatening arrhythmias — we manage the consequences of the disease, not the disease itself. Dosing the first patient with an investigational therapy designed to go after the genetic root cause is a real step forward for families affected by this rare genetic cardiomyopathy”
Atrium Therapeutics Doses First Patient in Corventis™, the First Interventional Clinical Trial for People Living with PRKAG2 Syndrome PR Newswire
-- Global Phase 1/2 trial will evaluate ATR 1072 in approximately 37 participants --
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