Corcept Therapeutics Announces Third Quarter Financial Results and Provides Corporate Update

Joseph K. Belanoff, MD, Chief Executive Officer of Corcept Therapeutics

“Awareness of the importance of diagnosing and treating patients with Cushing’s syndrome is steadily increasing and is driving the growth of our endocrinology business. Lifyorli’s uptake in ovarian cancer has been both very rapid and broad. Since its April 1(st) launch, more than 2,300 patients have received the medication. More than 1,700 physicians have prescribed it. We expect continued growth in both businesses and have reiterated our 2026 revenue guidance of $1.1 – $1.2 billion.”

Bill Guyer, PharmD, Chief Development Officer of Corcept Therapeutics

“The ADA and EASD consensus statement is an important advance for the many patients whose difficult-to-control hyperglycemia is a manifestation of undiagnosed Cushing’s syndrome. Optimal care starts with screening and a correct diagnosis. The ADA/EASD report also identifies mifepristone as a potential treatment, citing the positive results of our CATALYST trial.”

Bill Guyer, PharmD, Chief Development Officer of Corcept Therapeutics

“Substantial preclinical and clinical data suggest that our proprietary, selective glucocorticoid receptor (GR) antagonists benefit patients both by sensitizing their tumors to chemotherapy and by bolstering their immune system’s ability to combat the disease. Our goal is to establish GR antagonism as a mechanism for treating a broad range of solid tumors, in combination with a variety of anticancer therapies, at every stage of disease. Our BELLA Part A results provide the latest evidence of GR antagonism’s versatility, especially when administered earlier in the course of disease. Our current trials – BELLA (Parts B and C), TRIDENT and SYNERGY – will generate important data in 2027. But these studies are just the start. We are aggressively expanding our research activities, with the goal of helping many more patients.”

Bill Guyer, PharmD, Chief Development Officer of Corcept Therapeutics

“We are encouraged by the dose-dependent reductions in liver fat, and improvement in fibrosis observed at the very low doses of miricorilant administered in MONARCH. We plan to study higher doses, to see if miricorilant’s fat- and fibrosis-reducing activity can be realized without sacrificing its excellent tolerability.”

Bill Guyer, PharmD, Chief Development Officer of Corcept Therapeutics

“In our Phase 2 DAZALS study, treatment with a cortisol modulator was associated with a profound reduction in early mortality, during a period when many patients with ALS still retain significant function and maintain good quality of life. We plan to begin a Phase 3 study next year.”