FibroBiologics Presents Preclinical Data on Fibroblast Spheroid-Derived Chondrocyte Spheroids for Degenerative Disc Disease at the North American Spine Society 2026 Annual Meeting
PR Newswire•19/10/2026•08:30 ET
0
Key Highlights
- ➤FSdC spheroids preserved disc height better than other fibroblast approaches over 12 weeks
- ➤12-week disc height index reached 80.7% versus 71.8% for controls (p<0.05)
- ➤2D fibroblasts, fibroblast spheroids, and FSdC spheroids significantly improved disc height
- ➤FSdC spheroids showed cartilage differentiation through Alcian blue staining and gene upregulation
- ➤FibroBiologics presented the preclinical degenerative disc disease data at NASS 2026
Expert Statements
Hamid Khoja, Chief Scientific Officer of FibroBiologics
“Degenerative disc disease is driven by a loss of the cells and extracellular matrix that keep the disc functional, and our fibroblast spheroid platform is designed to address that biology directly.”
Hamid Khoja, Chief Scientific Officer of FibroBiologics
“The data presented at NASS show key findings such as matrix remodeling and reduced inflammation in degenerated discs, and we look forward to discussing these findings with the spine community as we continue advancing our programs.”
Nikolay Bazhanov, M.D., Ph.D., presenter on the study
“For people living with degenerative disc disease, treatment today largely comes down to managing pain or undergoing surgery, and neither approach is designed to restore the cells the disc has lost.”
Nikolay Bazhanov, M.D., Ph.D., presenter on the study
“FSdC spheroids are designed to potentially do exactly that, by delivering allogeneic cartilage-forming cells directly into the damaged disc.”
Nikolay Bazhanov, M.D., Ph.D., presenter on the study
“In this study, FSdCs preserved disc height better than any other approach we tested, and that advantage held for the full 12 weeks.”
FibroBiologics Presents Preclinical Data on Fibroblast Spheroid-Derived Chondrocyte Spheroids for Degenerative Disc Disease at the North American Spine Society 2026 Annual Meeting PR Newswire
FSdC Spheroids Preserved Disc Height Better Than Any Other Fibroblast-Based Approach Tested in a 12-Week Rabbit Model of Degenerative Disc Disease
Get started
Create a free account to read the full story.