Genprex Highlights New Preclinical Data Identifying Role of TUSC2, the Gene Used in REQORSA®, in Maintaining Cellular Function During Brain Aging
PR Newswire•21/10/2026•07:00 ET
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Key Highlights
- ➤TUSC2 loss disrupted mitochondrial, protein-homeostasis, and synaptic pathways in mice
- ➤TUSC2 effects were markedly more pronounced in male mice than females
- ➤TUSC2 expression declined with age in 11 of 13 examined brain regions
- ➤Human and mouse hippocampal data showed overlapping molecular aging changes
- ➤Study did not evaluate REQORSA as a treatment for aging or neurodegenerative disease
Expert Statements
Mark Berger, Chief Medical Officer of Genprex
“This research adds to our understanding of the diverse biological functions of TUSC2, the tumor suppressor gene at the center of our REQORSA oncology program.”
Mark Berger, Chief Medical Officer of Genprex
“The findings highlight the important role TUSC2 plays in mitochondrial function, cellular stress responses, and protein homeostasis, while revealing intriguing differences between males and females.”
Mark Berger, Chief Medical Officer of Genprex
“Importantly, the parallels identified between the preclinical findings and human brain aging data further reinforce the biological significance of TUSC2 beyond its established role in cancer.”
Mark Berger, Chief Medical Officer of Genprex
“While these findings are exploratory, they contribute to a growing body of research into the broader functions of this important gene.”
Genprex Highlights New Preclinical Data Identifying Role of TUSC2, the Gene Used in REQORSA®, in Maintaining Cellular Function During Brain Aging PR Newswire
Collaborators publish new peer-reviewed study identifying sex-specific effects of TUSC2 loss on mitochondrial function, protein homeostasis, and synaptic pathways, alongside molecular similarities with human brain
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