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Shattuck Labs Announces Phase 2 Clinical Trial of SL-325 in Hidradenitis Suppurativa and Appointment of Shoba Ravichandran, M.D., as Senior Vice President, Clinical Development

Globe Newswire•01/10/2026•07:00 ET
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Key Highlights

  • ➤RECEPTIVE-HS1 Phase 2 trial expected to initiate in 2026
  • ➤Approximately 150 patients planned for randomized HS trial
  • ➤Week 16 data expected in the first half of 2028
  • ➤Cash expected to fund Shattuck Labs (STTK) operations into 2029
  • ➤Shoba Ravichandran appointed Senior Vice President, Clinical Development

Expert Statements

Taylor Schreiber, Chief Executive Officer of Shattuck Labs

“We are excited to see the recent clinical validation of the TL1A/DR3 axis in patients with moderate to severe HS. We expect, by targeting DR3 instead of TL1A, SL-325 may provide potentially best-in-mechanism efficacy in indications where the TL1A/DR3 axis is proven active. Only a few biologic therapies are available to patients with moderate to severe HS, and the emerging data support the potential for TL1A/DR3 blockade to provide best-in-disease efficacy”

Taylor Schreiber, Chief Executive Officer of Shattuck Labs

“We are also very pleased to welcome Dr. Shoba Ravichandran to the team as Senior Vice President, Clinical Development. Dr. Ravichandran’s deep clinical development experience, including leading Cosentyx to approval in HS, will be important in driving toward Phase 2b data for the RECEPTIVE-HS1 study in the first half of 2028.”

Shoba Ravichandran, Senior Vice President, Clinical Development of Shattuck Labs

“I am delighted to join the Shattuck team and lead development of SL-325 in HS, a disease with very high unmet need and one where I believe SL-325 can be a differentiated and exciting future treatment option for patients.”

–RECEPTIVE-HS1 Phase 2 clinical trial in patients with moderate to

severe hidradenitis suppurativa (HS) expected to initiate in 2026; data from

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