TG Therapeutics Announces Publication of Five-Year Comparative Analysis of BRIUMVI Versus Ocrelizumab and Ofatumumab in Relapsing Multiple Sclerosis
Business Wire•12/10/2026•07:30 ET
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Key Highlights
- ➤BRIUMVI showed 44% lower CDP24 hazard versus ocrelizumab over five years
- ➤BRIUMVI showed 49% lower CDP24 hazard versus ofatumumab over five years
- ➤BRIUMVI CDP24 incidence was 9.3% versus 16.1% for ocrelizumab
- ➤BRIUMVI CDP24 incidence was 9.4% versus 17.9% for ofatumumab
- ➤BRIUMVI five-year MAIC-adjusted ARR declined to 0.032 versus ocrelizumab and 0.030 versus ofatumumab
Expert Statements
Michael S. Weiss, Chairman and Chief Executive Officer of TG Therapeutics
“In an era where physicians and patients are fortunate to have multiple anti-CD20 treatment options available for relapsing MS, the lack of comparative data makes choosing the right one challenging. This is particularly important for people living with a chronic disease like MS, where preventing the accumulation of disability over time is an important treatment goal.”
Michael S. Weiss, Chairman and Chief Executive Officer of TG Therapeutics
“In the absence of head-to-head clinical trials, MAIC provides a valuable statistical approach to evaluating comparative treatment outcomes while accounting for differences in patient populations across studies. We are encouraged that this analysis showed that BRIUMVI was associated with consistently lower relapse activity versus ocrelizumab and a lower risk of confirmed disability progression compared with both ocrelizumab and ofatumumab over five years. We believe these findings add to the growing body of evidence supporting the durable efficacy profile of BRIUMVI and its potential to provide meaningful long-term benefit for people living with MS.”
TG Therapeutics Announces Publication of Five-Year Comparative Analysis of BRIUMVI Versus Ocrelizumab and Ofatumumab in Relapsing Multiple Sclerosis
BRIUMVI was associated with a lower risk of 24-week confirmed disability progression and lower annualized relapse rates (ARRs) over five years compared with ocrelizumab and ofatumumab
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